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I do remember one formative influence in my undergraduate life. There was an elderly professor in my department who had been passionately keen on a particular theory for, oh, a number of years, and one day an American visiting researcher came and he completely and utterly disproved our old man's hypothesis. The old man strode to the front, shook his hand and said, "My dear fellow, I wish to thank you, I have been wrong these fifteen years". And we all clapped our hands raw. That was the scientific ideal, of somebody who had a lot invested, a lifetime almost invested in a theory, and he was rejoicing that he had been shown wrong and that scientific truth had been advanced. (Part 1, 00:13:32)

 

Richard Dawkins

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The theory is the result of listening to the problem. When the theory acquires a life of its own because some people like it more than the real world, all kinds of uninspiring, uninteresting things happen, so the key is both to listen to the problem and to study the theory. But always remember that just as much theory is bunk as there are buggy solutions. There is nothing more wrong with "theory" than "solutions" – both their quality and their applicability are orthogonal to their existence.

 

Erik Naggum

 

There is one feature I notice that is generally missing in "cargo cult science." It's a kind of scientific integrity, a principle of scientific thought that corresponds to a kind of utter honesty — a kind of leaning over backwards. For example, if you're doing an experiment, you should report everything that you think might make it invalid — not only what you think is right about it; other causes that could possibly explain your results; and things you thought of that you've eliminated by some other experiment, and how they worked — to make sure the other fellow can tell they have been eliminated.
Details that could throw doubt on your interpretation must be given, if you know them. You must do the best you can — if you know anything at all wrong, or possibly wrong — to explain it. If you make a theory, for example, and advertise it, or put it out, then you must also put down all the facts that disagree with it, as well as those that agree with it. There is also a more subtle problem. When you have put a lot of ideas together to make an elaborate theory, you want to make sure, when explaining what it fits, that those things it fits are not just the things that gave you the idea for the theory; but that the finished theory makes something else come out right, in addition.
In summary, the idea is to try to give all of the information to help others to judge the value of your contribution; not just the information that leads to judgment in one particular direction or another.

 

Richard Feynman

 

A theory can never be proven absolutely true, therefore there is no end to scientific endeavor. A true scientific theory is always open to be disproved, and the burden of proof is continually placed on the scientist.

 

Kristine Larsen

 

Any physical theory is always provisional, in the sense that it is only a hypothesis: you can never prove it. No matter how many times the results of experiments agree with some theory, you can never be sure that the next time the result will not contradict the theory. On the other hand, you can disprove a theory by finding even a single observation that disagrees with the predictions of the theory. As philosopher of science Karl Popper has emphasized, a good theory is characterized by the fact that it makes a number of predictions that could in principle be disproved or falsified by observation. Each time new experiments are observed to agree with the predictions the theory survives, and our confidence in it is increased; but if ever a new observation is found to disagree, we have to abandon or modify the theory.

 

Stephen Hawking

 

While the new physics was developing in the twentieth century, the mechanistic Cartesian world view and the principles of Newtonian physics maintained their strong influence on Western scientific thinking, and even today many scientists still hold to the mechanistic paradigm, although physicists themselves have gone beyond it.
However, the new conception of the universe that has emerged from modern physics does not mean that Newtonian physics is wrong, or that quantum theory, or relativity theory, is right. Modern science has come to realize that all scientific theories are approximations to the true nature of reality; and that each theory is valid for a certain range of phenomena.

 

Fritjof Capra