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Stephen Jay Gould

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[S]cience is often regarded as the most objective and truth-directed of human enterprises, and since direct observation is supposed to be the favored route to factuality, many people equate respectable science with visual scrutiny—just the facts ma'am, and palpably before my eyes. But science is a battery of observational and inferential methods, all directed to the testing of propositions that can, in principle, be definitely proven false. […] At all scales, from smallest to largest, quickest to slowest, many well-documented conclusions of science lie beyond the strictly limited domain of direct observation. No one has ever seen an electron or a black hole, the events of a picosecond or a geological eon.
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"Muller Bros. Moving & Storage", pp. 200–201

 
Stephen Jay Gould

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[H]istorical science is not worse, more restricted, or less capable of achieving firm conclusions because experiment, prediction, and subsumption under invariant laws of nature do not represent its usual working methods. The sciences of history use a different mode of explanation, rooted in the comparative and observational richness in our data. We cannot see a past event directly, but science is usually based on inference, not unvarnished observation (you don't see electrons, gravity, or black holes either).

 
Stephen Jay Gould
 

For the truth of the conclusions of physical science, observation is the supreme Court of Appeal. It does not follow that every item which we confidently accept as physical knowledge has actually been certified by the Court; our confidence is that it would be certified by the Court if it were submitted. But it does follow that every item of physical knowledge is of a form which might be submitted to the Court. It must be such that we can specify (although it may be impracticable to carry out) an observational procedure which would decide whether it is true or not. Clearly a statement cannot be tested by observation unless it is an assertion about the results of observation. Every item of physical knowledge must therefore be an assertion of what has been or would be the result of carrying out a specified observational procedure.

 
Arthur Stanley Eddington
 

The third aspect of my subject is that of science as a method of finding things out. This method is based on the principle that observation is the judge of whether something is so or not. All other aspects and characteristics of science can be understood directly when we understand that observation is the ultimate and final judge of the truth of an idea. But "prove" used in this way really means "test," in the same way that a hundred-proof alcohol is a test of the alcohol, and for people today the idea really should be translated as, "The exception tests the rule." Or, put another way, "The exception proves that the rule is wrong." That is the principle of science. If there is an exception to any rule, and if it can be proved by observation, that rule is wrong.

 
Richard Feynman
 

Galileo claimed to have discovered, by astronomical observation through a telescope, that Copernicus was right that the earth revolved around the sun. [Cardinal] Bellarmine claimed that he could not be right because his view ran counter to the Bible. Rorty says, astoundingly, that Bellarmine's argument was just as good as Galileo's. It is just that the rhetoric of "science" had not at that time been formed as part of the culture of Europe. We have now accepted the rhetoric of "science," he writes, but it is not more objective or rational than Cardinal Bellarmine's explicitly dogmatic Catholic views. According to Rorty, there is no fact of the matter about who was right because there are no absolute facts about what justifies what. Bellarmine and Galileo, in his view, just had different epistemic systems. [...] Bellarmine and Galileo reached different conclusions but they worked, like everyone else, within exactly the same system of rationality. Bellarmine [actually] held the false view that the Bible was a reliable astronomical authority. But that is a case of a false presupposition, not an alternative epistemic rationality.

 
Richard Rorty
 

Do I worship modern medicine? Is science my religion? Not at all; there is no aspect of modern medicine or science that I would exempt from the most rigorous scrutiny, and I can readily identify a host of serious problems that still need to be fixed. That's easy to do, of course, because the worlds of medicine and science are already engaged in the most obsessive, intensive, and humble self-assessments yet known to human institutions, and they regularly make public the results of their self-examinations. Moreover, this open-ended rational criticism, imperfect as it is, is the secret of the astounding success of these human enterprises. There are measurable improvements every day.

 
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