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John Quincy Adams

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Courage and perseverance have a magical talisman, before which difficulties disappear and obstacles vanish into air. These qualities have ever been displayed in their mightiest perfection, as attendants in the retinue of strong passions.
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In recent years this has often been misquoted as: "Patience and perseverance have a magical effect before which difficulties disappear and obstacles vanish".

 
John Quincy Adams

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The enchanting charms of this sublime science reveal themselves in all their beauty only to those who have the courage to go deeply into it. But when a person of that sex, that, because of our mores and our prejudices, has to encounter infinitely more obstacles and difficulties than men in familiarizing herself with these thorny research problems, nevertheless succeeds in surmounting these obstacles and penetrating their most obscure parts, she must without doubt have the noblest courage, quite extraordinary talents and superior genius.

 
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Invariably will you find perseverance exemplified as the radical principle in every truly great character. It facilitates, perfects, and consolidates the execution of the plan conceived, and renders profitable its results when attained. By continuing to advance steadily in the same way, light constantly increases, obstacles disappear, efficient habits are confirmed, experience is acquired, the use of the best means is reduced to easy action, and success becomes more sure.

 
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Research is a matter of overcoming obstacles. That's what research is about. There are problems. There are difficulties. It's hard to make sense of a collection of information or whatever. Obstacles are the nature of research. Maybe that's why some people give up. There's always an obstacle. You overcome one to find there's another one.

 
Alexander Dalgarno
 

The path to perfection is difficult to men in every lot; there is no royal road for rich or poor. But difficulties are meant to rouse, not discourage. The human spirit is to grow strong by conflict. And how much has it already overcome! Under what burdens of oppression has it made its way for ages What mountains of difficulty has it cleared! And with all this experience, shall we say that the progress of the mass of men is to be despaired of; that the chains of bodily necessity are too strong and ponderous to be broken by the mind; that servile, unimproving drudgery is the unalterable condition of the multitude of the human race?

 
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The hand of God never tires, nor are its movements aimless. It makes all things subservient to its designs, and, at every turn, disappoints the calculations of man, causing the most insignificant events to expand to the mightiest consequences, while those that have the appearance of mountains vanish into nothing.

 
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