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According to the most influential twentieth-century philosopher of science, Karl Popper, a theory is scientific only in so far as it is falsifiable, and should be given up as soon as it has been falsified. By this standard, the theories of Darwin and Einstein should never have been accepted.
--
The Human: Science's Irrational Origins (p. 22)

 

John N. Gray

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The Steady State theory was what Karl Popper would call a good scientific theory: it made definite predictions, which could be tested by observation, and possibly falsified. Unfortunately for the theory, they were falsified.

 

Stephen Hawking

 

Any physical theory is always provisional, in the sense that it is only a hypothesis: you can never prove it. No matter how many times the results of experiments agree with some theory, you can never be sure that the next time the result will not contradict the theory. On the other hand, you can disprove a theory by finding even a single observation that disagrees with the predictions of the theory. As philosopher of science Karl Popper has emphasized, a good theory is characterized by the fact that it makes a number of predictions that could in principle be disproved or falsified by observation. Each time new experiments are observed to agree with the predictions the theory survives, and our confidence in it is increased; but if ever a new observation is found to disagree, we have to abandon or modify the theory.

 

Stephen Hawking

 

The progress of human knowledge depends on maintaining that touch of scepticism even about the most "unquestionable" truths. A century ago, Darwin's theory of evolution by natural selection was regarded as scientifically unshakeable; today, most biologists have their reservations about it. Fifty years ago, Freud's sexual theory of neurosis was accepted by most psychiatrists; today, it is widely recognized that his methods were highly questionable. At the turn of this century, a scientist who questioned Newton's theory of gravity would have been regarded as insane; twenty years later, it had been supplanted by Einstein's theory, although, significantly, few people actually understood it. It seems perfectly conceivable that our descendants of the twenty-second century will wonder how any of us could have been stupid enough to have been taken in by Darwin, Freud or Einstein.

 

Colin Wilson

 

An open society such as ours is based on the recognition that our understanding of reality is inherently imperfect. Nobody is in possession of the ultimate truth. As the philosopher Karl Popper has shown, the ultimate truth is not attainable even in science. All theories are subject to testing and the process of replacing old theories with better ones never ends.

 

George Soros

 

While the new physics was developing in the twentieth century, the mechanistic Cartesian world view and the principles of Newtonian physics maintained their strong influence on Western scientific thinking, and even today many scientists still hold to the mechanistic paradigm, although physicists themselves have gone beyond it.
However, the new conception of the universe that has emerged from modern physics does not mean that Newtonian physics is wrong, or that quantum theory, or relativity theory, is right. Modern science has come to realize that all scientific theories are approximations to the true nature of reality; and that each theory is valid for a certain range of phenomena.

 

Fritjof Capra