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Immanuel Kant

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There can be no doubt that all our knowledge begins with experience.
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Immanuel Kant

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The scientist has a lot of experience with ignorance and doubt and uncertainty, and this experience is of very great importance, I think. When a scientist doesn’t know the answer to a problem, he is ignorant. When he has a hunch as to what the result is, he is uncertain. And when he is pretty damn sure of what the result is going to be, he is still in some doubt. We have found it of paramount importance that in order to progress, we must recognize our ignorance and leave room for doubt. Scientific knowledge is a body of statements of varying degrees of certainty — some most unsure, some nearly sure, but none absolutely certain. Now, we scientists are used to this, and we take it for granted that it is perfectly consistent to be unsure, that it is possible to live and not know. But I don’t know whether everyone realizes this is true. Our freedom to doubt was born out of a struggle against authority in the early days of science. It was a very deep and strong struggle: permit us to question — to doubt — to not be sure. I think that it is important that we do not forget this struggle and thus perhaps lose what we have gained.

 
Richard Feynman
 

Aristotle’s view that philosophy begins with wonder, not as in our day with doubt, is a positive point of departure for philosophy. Indeed, the world will no doubt learn that it does not do to begin with the negative, and the reason for success up to the present is that philosophers have never quite surrendered to the negative and thus have never earnestly done what they have said. They merely flirt with doubt.

 
Soren Aabye Kierkegaard
 

The absurd … is an experience to be lived through, a point of departure, the equivalent, in existence of Descartes' methodical doubt. Absurdism, like methodical doubt, has wiped the slate clean. It leaves us in a blind alley. But, like methodical doubt, it can, by returning upon itself, open up a new field of investigation, and in the process of reasoning then pursues the same course. I proclaim that I believe in nothing and that everything is absurd, but I cannot doubt the validity of my proclamation and I must at least believe in my protest. The first and only evidence that is supplied me, within the terms of the absurdist experience, is rebellion … Rebellion is born of the spectacle of irrationality, confronted with an unjust and incomprehensible condition.

 
Albert Camus
 

The Garden of Eden was closed; everything was changed, the man became afraid of himself, afraid of the world around him. Troubled he asked: What is the good, where is the perfect to be found? If it exists, where is its source? But the doubt that had come along with the knowledge coiled itself alarmingly around his heart, and the serpent that had seduced him with the delectable now squeezed him in its coils. Would he find out what the good and perfect is without learning where it came from, would he be able to recognize the eternal source without knowing what the good and perfect is? Doubt would explain to him first one thing, then another, and in the explanation itself would lie in wait for him in order to disquiet him still more. What happened at the beginning of days is repeated in every generation and in the individual; the consequences of the fruit of the knowledge could not be halted. With the knowledge, doubt became more inward, and the knowledge, which should have guided man, fettered him in distress and contradiction. Eighteen Upbuilding Discourses, Hong, p. 127

 
Soren Aabye Kierkegaard
 

Experience isn't interesting until it begins to repeat itself - in fact, till it does that, it hardly is experience.

 
Elizabeth Bowen
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