Both of us had decided, quite independently of each other, that the central problem in molecular biology was the chemical structure of the gene.
Francis Crick
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My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure,” I was supposed to have said in my molecular biology days. (I believe I was sailing at the time.) I think that one should approach these problems at all levels, as was done in molecular biology. Classical genetics is, after all, a black-box subject. The important thing was to combine it with biochemistry. In nature hybrid species are usually sterile, but in science the reverse is often true. Hybrid subjects are often astonishingly fertile, whereas if a scientific discipline remains too pure it usually wilts.
Francis Crick
We may, I believe, anticipate that the chemist of the future who is interested in the structure of proteins, nucleic acids, polysaccharides, and other complex substances with high molecular weight will come to rely upon a new structural chemistry, involving precise geometrical relationships among the atoms in the molecules and the rigorous application of the new structural principles, and that great progress will be made, through this technique, in the attack, by chemical methods, on the problems of biology and medicine.
Linus Pauling
Linus Pauling was not always right in his ideas. But my belief is that, in most cases, if somebody is always right in his ideas you find that he does not have much to say. It is an expression of somebody's fertility that he does produce quite a number of ideas, and I think Linus Pauling's score is pretty high... I do not think, as I said earlier, that it is right to discuss the impact of Linus Pauling on molecular biology. Rather, he was one of the founders of molecular biology. It was not that it existed in some way, and he simply made a contribution. He was one of the founders who got the whole discipline going.
Linus Pauling
In biology the Cartesian view of living organisms as machines, constructed from separate parts, still provides the dominant conceptual framework. Although Descartes' simple mechanistic biology could not be carried very far and had to be modified considerably during the subsequent three hundred years, the belief that all aspects of living organisms can be understood by reducing them to their smallest constituents, and by studying the mechanisms through which these interact, lies at the very basis of most contemporary biological thinking. This passage from a current textbook on modern biology is a clear expression of the reductionist credo: 'One of the acid tests of understanding an object is the ability to put it together from its component parts. Ultimately, molecular biologists will attempt to subject their understanding of cell structure and function to this sort of test by trying to synthesize a cell
Fritjof Capra
In biology the Cartesian view of living organisms as machines, constructed from separate parts, still provides the dominant conceptual framework. Although Descartes' simple mechanistic biology could not be carried very far and had to be modified considerably during the subsequent three hundred years, the belief that all aspects of living organisms can be understood by reducing them to their smallest constituents, and by studying the mechanisms through which these interact, lies at the very basis of most contemporary biological thinking. This passage from a current textbook on modern biology is a clear expression of the reductionist credo: 'One of the acid tests of understanding an object is the ability to put it together from its component parts. Ultimately, molecular biologists will attempt to subject their understanding of cell structure and function to this sort of test by trying to synthesize a cell
Fritjof Capra
Crick, Francis
Crichton, Michael
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