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Everything that has been said, and every conclusion that has been tentatively put forward, is quite frankly speculative and uncertain. We have tried to discuss whether present-day science has anything to say on certain difficult questions, which are perhaps set for ever beyond the reach of human understanding. We cannot claim to have discerned more than a very faint glimmer of light at the best; perhaps it was wholly illusory, for certainly we had to strain our eyes very hard to see anything at all. So that our main contention can hardly be that the science of to-day has a pronouncement to make, perhaps it ought rather to be that science should leave off making pronouncements: the river of knowledge has too often turned back on itself.
--
The closing sentences of the book, on p. 188 of Pelican Books 1938 reprint of 1931 2nd ed.

 

James Jeans

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Science talks about very simple things, and asks hard questions about them. As soon as things become too complex, science can't deal with them... But it's a complicated matter: Science studies what's at the edge of understanding, and what's at the edge of understanding is usually fairly simple. And it rarely reaches human affairs. Human affairs are way too complicated. In fact even understanding insects is an extremely complicated problem in the sciences. So the actual sciences tell us virtually nothing about human affairs.

 

Noam Chomsky

 

I think the new science fiction, which other people apart from myself are now beginning to write, is introverted, possibly pessimistic rather than optimistic, much less certain of its own territory. There's a tremendous confidence that radiates through all modern American science fiction of the period 1930 to 1960; the certainty that science and technology can solve all problems. This is not the dominant form of science fiction now. I think science fiction is becoming something much more speculative, much less convinced about the magic of science and the moral authority of science. There's far more caution on the part of the new writers than there was.

 

J. G. Ballard

 

Historically, the claim of consensus has been the first refuge of scoundrels; it is a way to avoid debate by claiming that the matter is already settled. Whenever you hear the consensus of scientists agrees on something or other, reach for your wallet, because you're being had.
Let's be clear: the work of science has nothing whatever to do with consensus. Consensus is the business of politics. Science, on the contrary, requires only one investigator who happens to be right, which means that he or she has results that are verifiable by reference to the real world. In science consensus is irrelevant. What is relevant is reproducible results. The greatest scientists in history are great precisely because they broke with the consensus. There is no such thing as consensus science. If it's consensus, it isn't science. If it's science, it isn't consensus. Period.

 

Michael Crichton

 

If you sense a deep human need, then you go back to all the basic science. If there is some missing, then you try to do more basic science and applied science until you get it. So you make the system to fulfill that need, rather than starting the other way around, where you have something and wonder what to do with it.

 

Edwin H. Land

 

Science is feasible when the variables are few and can be enumerated; when their combinations are distinct and clear. We are tending toward the condition of science and aspiring to do it. The artist works out his own formulas; the interest of science lies in the art of making science.

 

Paul Valery