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I do not fear death. I had been dead for billions and billions of years before I was born, and had not suffered the slightest inconvenience from it.
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Quoted in Dawkins, Richard (2006). "A Much Needed Gap?". The God Delusion. Bantam Press. p. 354. ISBN 0-618-68000-4. , but no source is given. Note that during Twain's life the Age of the Earth was thought to be measured in tens of millions not billions of years.
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A video of Dawkins crediting Twain for the quote.

 

Samuel Langhorne Clemens (Mark Twain)

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I never said it. Honest. Oh, I said there are maybe 100 billion galaxies and 10 billion trillion stars. It's hard to talk about the Cosmos without using big numbers. I said 'billion' many times on the Cosmos television series, which was seen by a great many people. But I never said 'billions and billions.' For one thing, it's imprecise. How many billions are 'billions and billions'? A few billion? Twenty billion? A hundred billion? 'Billions and billions' is pretty vague... For a while, out of childish pique, I wouldn't utter the phrase, even when asked to. But I've gotten over that. So, for the record, here it goes: 'Billions and billions.'

 

Carl Sagan

 

How good is it to remember one's insignificance: that of a man among billions of men, of an animal amid billions of animals; and one's abode, the earth, a little grain of sand in comparison with Sirius and others, and one's life span in comparison with billions on billions of ages. There is only one significance, you are a worker. The assignment is inscribed in your reason and heart and expressed clearly and comprehensibly by the best among the beings similar to you. The reward for doing the assignment is immediately within you. But what the significance of the assignment is or of its completion, that you are not given to know, nor do you need to know it. It is good enough as it is. What else could you desire?

 

Leo Tolstoy

 

Why it is that of all the billions and billions of strange objects in the Cosmos — novas, quasars, pulsars, black holes — you are beyond doubt the strangest?

 

Walker Percy

 

Once we overcome our fear of being tiny, we find ourselves on the threshold of a vast and awesome Universe that utterly dwarfs — in time, in space, and in potential — the tidy anthropocentric proscenium of our ancestors. We gaze across billions of light-years of space to view the Universe shortly after the Big Bang, and plumb the fine structure of matter. We peer down into the core of our planet, and the blazing interior of our star. We read the genetic language in which is written the diverse skills and propensities of every being on Earth. We uncover hidden chapters in the record of our origins, and with some anguish better understand our nature and prospects. We invent and refine agriculture, without which almost all of us would starve to death. We create medicines and vaccines that save the lives of billions. We communicate at the speed of light, and whip around the Earth in an hour and a half. We have sent dozens of ships to more than seventy worlds, and four spacecraft to the stars. We are right to rejoice in our accomplishments, to be proud that our species has been able to see so far, and to judge our merit in part by the very science that has so deflated our pretensions.

 

Carl Sagan