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"Are we making more mistakes now? I don't think so. Science is a high-risk activity. And when you do science--this is very important incidentally for the general public, and for policy makers--if you are not wasting some of your money, you are not doing good science. It's a funny way to say this. You've got to back high-risk opportunities. And high-risk opportunities means some fraction of them are going to fail. And I think in any science funding scenario, you've got to say, 10, 20, maybe even 30% of your funds are going to be invested in failures.
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Comments on need for failure in scientific research.
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From the Winding Your Way through DNA symposium at the University of California, San Francisco in 1992. (url accessed on October 20, 2008)

 

Leon M. Lederman

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There are two kinds of truth: the truth that lights the way and the truth that warms the heart. The first of these is science, and the second is art. Neither is independent of the other or more important than the other. Without art science would be as useless as a pair of high forceps in the hands of a plumber. Without science art would become a crude mess of folklore and emotional quackery. The truth of art keeps science from becoming inhuman, and the truth of science keeps art from becoming ridiculous.

 

Raymond Chandler

 

It seems to me that science has a much greater likelihood of being true in the main than any philosophy hitherto advanced (I do not, of course, except my own). In science there are many matters about which people are agreed; in philosophy there are none. Therefore, although each proposition in a science may be false, and it is practically certain that there are some that are false, yet we shall be wise to build our philosophy upon science, because the risk of error in philosophy is pretty sure to be greater than in science. If we could hope for certainty in philosophy, the matter would be otherwise, but so far as I can see such a hope would be chimerical.

 

Bertrand Russell

 

All economic activity is by definition "high risk." And defending yesterday--that is, not innovating--is far more risky than making tomorrow.

 

Peter F. Drucker

 

Science is feasible when the variables are few and can be enumerated; when their combinations are distinct and clear. We are tending toward the condition of science and aspiring to do it. The artist works out his own formulas; the interest of science lies in the art of making science.

 

Paul Valery

 

In this chapter I want to raise the question partly in jest but partly also in seriousness whether the concept of the image cannot become the abstract foundation of a new science, or at least a cross-disciplinary specialization. As I am indulging in the symbolic communication of an image of images I will even venture to give the science a name — Eiconics — hoping thereby to endow it in the minds of my readers with some of the prestige of classical antiquity. I run some risk perhaps of having my new science confused with the study of icons. A little confusion, however, and the subtle overtones of half-remembered associations are all part of the magic of the name.

 

Kenneth Boulding