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Undoubtedly it is our duty, and for our best good, that we occupy and improve the faculties, with which our creator has endowed us, but so far as prejudice, or prepossession of opinion prevails over our minds, in the same proportion, reason is excluded from our theory or practice. Therefore if we would acquire useful knowledge, we must first divest ourselves of those impediments and sincerely endeavor to search out the truth: and draw our conclusions from reason and just argument, which will never conform to our inclination, interest or fancy but we must conform to that if we would judge rightly.
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Ch. XIII Section II - Of The Importance of the Exercise of Reason, and Practice of Morality, in order to the Happiness of Mankind

 

Ethan Allen

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Your reason is now mature enough to examine this object [religion]. In the first place divest yourself of all bias in favour of novelty & singularity of opinion. Indulge them in any other subject rather than that of religion. It is too important, & the consequences of error may be too serious. On the other hand shake off all the fears & servile prejudices under which weak minds are servilely crouched. Fix reason firmly in her seat, and call to her tribunal every fact, every opinion. Question with boldness even the existence of a god; because, if there be one, he must more approve the homage of reason, than that of blindfolded fear.

 

Thomas Jefferson

 

That the threat is now intense is not a reason to abandon our quest for knowledge. It is a reason to hold it more tightly, in spite of the need for action to preserve our freedom, in spite of the distractions of living in turmoil, that it may not be lost or brushed aside by the demands of the hour. We would not neglect our duty to our country and our fellows to strive mightily to preserve our ways and our lives. There is an added duty, not inconsistent, not less. It is the duty to so live that there may be a reason for living, beyond the mere mechanisms of life. It is the duty to carry on, under stress, the search for understanding.

 

Vannevar Bush

 

The words of God are justified, as I will show, by the fact that Job abandoned his first very erroneous opinion, and himself proved that it was an error. It is the opinion which suggests itself as plausible at first thought, especially in the minds of those who meet with mishap, well knowing that they have not merited them through sins. This is admitted by all, and therefore this opinion was assigned to Job. But he is represented to hold this view only so long as he was without wisdom, and knew God only by tradition, in the same manner as religious people generally know Him. As soon as he had acquired a true knowledge of God, he confessed that there is undoubtedly true felicity in the knowledge of God; it is attained by all who acquire that knowledge, and no earthly trouble can disturb it. So long as Job's knowledge of God was based on tradition and communication, and not on research, he believed that such imaginary good as is possessed in health, riches, and children, was the utmost that men can attain; this was the reason why he was in perplexity, and why he uttered the... opinions, and this is also the meaning of his words: "I have heard of thee by the hearing of the ear; but now mine eye seeth thee. Wherefore I abhor myself, and repent because of dust and ashes" (xlii. 5, 6); that is to say, he abhorred all that he had desired before, and that he was sorry that he had been in dust and ashes; comp. "and he sat down among the ashes" (ii. 8) On account of this last utterance, which implies true perception, it is said afterwards in reference to him, "for you have not spoken of me the thing that is right, as my servant Job hath."

 

Maimonides

 

We know truth, not only by the reason, but also by the heart, and it is in this last way that we know first principles; and reason, which has no part in it, tries in vain to impugn them. The sceptics, who have only this for their object, labour to no purpose. We know that we do not dream, and however impossible it is for us to prove it by reason, this inability demonstrates only the weakness of our reason, but not, as they affirm, the uncertainty of all our knowledge. For the knowledge of first principles, as space, time, motion, number, is as sure as any of those which we get from reasoning. And reason must trust these intuitions of the heart, and must base them on every argument. (We have intuitive knowledge of the tri-dimensional nature of space, and of the infinity of number, and reason then shows that there are no two square numbers one of which is double of the other. Principles are intuited, propositions are inferred, all with certainty, though in different ways.) And it is as useless and absurd for reason to demand from the heart proofs of her first principles, before admitting them, as it would be for the heart to demand from reason an intuition of all demonstrated propositions before accepting them.
This inability ought, then, to serve only to humble reason, which would judge all, but not to impugn our certainty, as if only reason were capable of instructing us. Would to God, on the contrary, that we had never need of it, and that we knew everything by instinct and intuition! But nature has refused us this boon. On the contrary, she has given us but very little knowledge of this kind; and all the rest can be acquired only by reasoning.
Therefore, those to whom God has imparted religion by intuition are very fortunate, and justly convinced. But to those who do not have it, we can give it only by reasoning, waiting for God to give them spiritual insight, without which faith is only human, and useless for salvation.

 

Blaise Pascal

 

If man is not to do more harm than good in his efforts to improve the social order, he will have to learn that in this, as in all other fields where essential complexity of an organized kind prevails, he cannot acquire the full knowledge which would make mastery of the events possible. He will therefore have to use what knowledge he can achieve, not to shape the results as the craftsman shapes his handiwork, but rather to cultivate a growth by providing the appropriate environment, in the manner in which the gardener does this for his plants.

 

Friedrich Hayek