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In fact, of course, science is an unparalleled playground of the imagination, populated by unlikely characters with wonderful names (messenger RNA, black holes, quarks) and capable of performing the most amazing deeds: sub-atomic whirling dervishes that can be in several places - everywhere and nowhere - at the same time; molecular hoop-snakes biting their own tails; self-copying spiral staircases bearing coded instructions; miniature keys searching for the locks in which they fit, on floating odysseys in a trillion synaptic gulfs.
--
"Reflections on 'A Conversation With Einstein's Brain'" in The Mind's I (1981), Douglas R. Hofstadter and Daniel C. Dennett, eds.

 

Daniel C. Dennett

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It’s time for us to wake up and face the truth, that we are a captive species on a prison planet, but the fact that we are so close to understanding the science of our imprisonment means that we are also just beginning to touch the key that locks the door, and if we are strong, if we defy and defeat the sinister forces that rule us now, we have a chance at last to unlock this place and do what we are able to do, that we are richly capable of doing, that those who love us—and they are out there, too—have hoped and sought that we should do from time immemorial.

 

Whitley Strieber

 

[H]istorical science is not worse, more restricted, or less capable of achieving firm conclusions because experiment, prediction, and subsumption under invariant laws of nature do not represent its usual working methods. The sciences of history use a different mode of explanation, rooted in the comparative and observational richness in our data. We cannot see a past event directly, but science is usually based on inference, not unvarnished observation (you don't see electrons, gravity, or black holes either).

 

Stephen Jay Gould

 

I'm sorry to disappoint science fiction fans, but if information is preserved, there is no possibility of using black holes to travel to other universes. If you jump into a black hole, your mass energy will be returned to our universe but in a mangled form which contains the information about what you were like but in a state where it can not be easily recognized. It is like burning an encyclopedia. Information is not lost, if one keeps the smoke and the ashes. But it is difficult to read. In practice, it would be too difficult to re-build a macroscopic object like an encyclopedia that fell inside a black hole from information in the radiation, but the information preserving result is important for microscopic processes involving virtual black holes.

 

Stephen Hawking

 

My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure,” I was supposed to have said in my molecular biology days. (I believe I was sailing at the time.) I think that one should approach these problems at all levels, as was done in molecular biology. Classical genetics is, after all, a black-box subject. The important thing was to combine it with biochemistry. In nature hybrid species are usually sterile, but in science the reverse is often true. Hybrid subjects are often astonishingly fertile, whereas if a scientific discipline remains too pure it usually wilts.

 

Francis Crick

 

The second requirement of a virus-friendly environment – that it should obey a program of coded instructions – is again only quantitatively less true for brains than for cells or computers. We sometimes obey orders from one another, but also we sometimes don't. Nevertheless, it is a telling fact that, the world over, the vast majority of children follow the religion of their parents rather than any of the other available religions. Instructions to genuflect, to bow towards Mecca, to nod one's head rhythmically towards the wall, to shake like a maniac, to "speak in tongues" – the list of such arbitrary and pointless motor patterns offered by religion alone is extensive – are obeyed, if not slavishly, at least with some reasonably high statistical probability.

 

Richard Dawkins