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We may, I believe, anticipate that the chemist of the future who is interested in the structure of proteins, nucleic acids, polysaccharides, and other complex substances with high molecular weight will come to rely upon a new structural chemistry, involving precise geometrical relationships among the atoms in the molecules and the rigorous application of the new structural principles, and that great progress will be made, through this technique, in the attack, by chemical methods, on the problems of biology and medicine.
--
Nobel Lecture (11 December 1954)

 

Linus Pauling

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Looked at from the perspective of twentieth-century earth, we see three great stages in the dynamic process of the universe. To this whole process, as it spreads out over perhaps ten billion years of time and ten billion light years of space, we give the name evolution, and we see three great patterns within it. The first is physical evolution. This presumably started with the development of the most elementary particles (whatever they may be); then of neutrons, protons, electrons, and radiations; then of elements from hydrogen to uranium and beyond formed by combining protons and electrons; then of chemical compounds; then finally of increasingly complex molecules from amino acids, and proteins to the great watershed of DNA, the beginnings of life.

 

Kenneth Boulding

 

I can see no practical application of molecular biology to human affairs... DNA is a tangled mass of linear molecules in which the informational content is quite inaccessible.

 

Frank Macfarlane Burnet

 

Both of us had decided, quite independently of each other, that the central problem in molecular biology was the chemical structure of the gene.

 

Francis Crick

 

I have described at some length the application of Positive Rays to chemical analysis; one of the main reasons for writing this book was the hope that it might induce others, and especially chemists, to try this method of analysis. I feel sure that there are many problems in chemistry, which could be solved with far greater ease by this than any other method. The method is surprisingly sensitive — more so than even that of spectrum analysis, requires an infinitesimal amount of material, and does not require this to be specially purified; the technique is not difficult if appliances for producing high vacua are available.

 

J. J. Thomson

 

My own prejudices are exactly the opposite of the functionalists’: “If you want to understand function, study structure,” I was supposed to have said in my molecular biology days. (I believe I was sailing at the time.) I think that one should approach these problems at all levels, as was done in molecular biology. Classical genetics is, after all, a black-box subject. The important thing was to combine it with biochemistry. In nature hybrid species are usually sterile, but in science the reverse is often true. Hybrid subjects are often astonishingly fertile, whereas if a scientific discipline remains too pure it usually wilts.

 

Francis Crick