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Do not be too timid and squeamish about your actions. All life is an experiment. The more experiments you make the better.
--
11 November 1842.

 

Ralph Waldo Emerson

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In science, conjecture drives both experiment and theory for it is only by forming conjectures (hypotheses) that we can make the direction of our experiments and theories informed. If such and such is true, then I should be able to do this experiment and look for this particular result or I should be able to find this theoretical formulation. Conversely, experiment and theory drive conjecture. One makes a startling observation or has a sudden insight and begins to speculate on its significance and implications and to draw possible conclusions (conjecture).

 

Robert Curl

 

Unfortunately, all life on earth - the only life we know - represents, for all its current variety, the results of a single experiment, for every earthly species evolved from the common ancestry of a single origin. We desperately need a repetition of the experiment (several would be better, but let's not be greedy!) in order to make a judgement. Mars represents our first real hope for a second experiment - the sine qua non - for any proper answer for the question of questions.

 

Stephen Jay Gould

 

Modern experimentation is often like driving an automobile. The details and theory of the instruments being used in the experiment are not known to the experimenter except in a very general way. (...) Experimenters are taught in an explicit way, often, how to write up reports of their experiments. But the tradition here is like sports reporting. Only the results of the experiment are reported in any serious detail. The procedures are not.

 

Patrick Suppes

 

One's tendency when one is young is to do experiments just to see what will happen, without really looking for specific things at all. I first set up a little laboratory in the attic at home just to grow crystals or try experiments described in books, such as adding a lot of concentrated sulfuric acid to the blood from a nosebleed which precipitates hemotin from the hemoglobin in the blood. That was quite a nice experiment. I still remember it.

 

Dorothy Hodgkin

 

All experiments in psychology are not of this [cargo cult] type, however. For example there have been many experiments running rats through all kinds of mazes, and so on — with little clear result. But in 1937 a man named Young did a very interesting one. He had a long corridor with doors all along one side where the rats came in, and doors along the other side where the food was. He wanted to see if he could train rats to go to the third door down from wherever he started them off. No. The rats went immediately to the door where the food had been the time before.
The question was, how did the rats know, because the corridor was so beautifully built and so uniform, that this was the same door as before? Obviously there was something about the door that was different from the other doors. So he painted the doors very carefully, arranging the textures on the faces of the doors exactly the same. Still the rats could tell. Then he thought maybe they were smelling the food, so he used chemicals to change the smell after each run. Still the rats could tell. Then he realized the rats might be able to tell by seeing the lights and the arrangement in the laboratory like any commonsense person. So he covered the corridor, and still the rats could tell.
He finally found that they could tell by the way the floor sounded when they ran over it. And he could only fix that by putting his corridor in sand. So he covered one after another of all possible clues and finally was able to fool the rats so that they had to learn to go to the third door. If he relaxed any of his conditions, the rats could tell.
Now, from a scientific standpoint, that is an A-number-one experiment. That is the experiment that makes rat-running experiments sensible, because it uncovers the clues that the rat is really using — not what you think it's using. And that is the experiment that tells exactly what conditions you have to use in order to be careful and control everything in an experiment with rat-running.
I looked into the subsequent history of this research. The next experiment, and the one after that, never referred to Mr. Young. They never used any of his criteria of putting the corridor on sand, or of being very careful. They just went right on running rats in the same old way, and paid no attention to the great discoveries of Mr. Young, and his papers are not referred to, because he didn't discover anything about rats. In fact, he discovered all the things you have to do to discover something about rats. But not paying attention to experiments like that is a characteristic of cargo cult science.

 

Richard Feynman