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Paul Dirac

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The underlying physical laws necessary for the mathematical theory of a large part of physics and the whole of chemistry are thus completely known, and the difficulty is only that the exact application of these laws leads to equations much too complicated to be soluble. It therefore becomes desirable that approximate practical methods of applying quantum mechanics should be developed, which can lead to an explanation of the main features of complex atomic systems without too much computation.
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Proceedings of the Royal Society of London. Series A, Containing Papers of a Mathematical and Physical Character, Vol. 123, No. 792 (6 April 1929)

 
Paul Dirac

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The first question we should face is: What is the aim of a physical theory? To this question diverse answers have been made, but all of them may be reduced to two main principles:
"A physical theory," certain logicians have replied, "has for its object the explanation of a group of laws experimentally established."
"A physical theory," other thinkers have said, "is an abstract system whose aim is to summarize and classify logically a group of experimental laws without claiming to explain these laws...
Now these two questions — Does there exist a material reality distinct from sensible appearances? and What is the nature of reality? — do not have their source in experimental method, which is acquainted only with sensible appearances and can discover nothing beyond them. The resolution of these questions transcends the methods used by physics; it is the object of metaphysics.
Therefore, if the aim of physical theories is to explain experimental laws, theoretical physics is not an autonomous science; it is subordinate to metaphysics...
Now, to make physical theories depend on metaphysics is surely not the way to let them enjoy the privilege of universal consent.

 
Pierre Duhem
 

However, many applied optimization problems have not been considered yet. It is necessary to use optimization methods of quantum and bio-molecular systems, because of the practical importance of the implementation of physical processes satisfying the required quality criteria. Most of the attention is focused on the following problems: … 2. Mathematical modeling of controlled physical and chemical processes in the brain; [to] consider the brain as a quantum macroscopic object (Gomatam, 1999).

 
Ravi Gomatam
 

The ultimate objective test of free will would seem to be: Can one predict the behavior of the organism? If one can, then it clearly doesn't have free will but is predetermined. On the other hand, if one cannot predict the behavior, one could take that as an operational definition that the organism has free will ... The real reason why we cannot predict human behavior is that it is just too difficult. We already know the basic physical laws that govern the activity of the brain, and they are comparatively simple. But it is just too hard to solve the equations when there are more than a few particles involved ... So although we know the fundamental equations that govern the brain, we are quite unable to use them to predict human behavior. This situation arises in science whenever we deal with the macroscopic system, because the number of particles is always too large for there to be any chance of solving the fundamental equations. What we do instead is use effective theories. These are approximations in which the very large number of particles are replaced by a few quantities. An example is fluid mechanics ... I want to suggest that the concept of free will and moral responsibility for our actions are really an effective theory in the sense of fluid mechanics. It may be that everything we do is determined by some grand unified theory. If that theory has determined that we shall die by hanging, then we shall not drown. But you would have to be awfully sure that you were destined for the gallows to put to sea in a small boat during a storm. I have noticed that even people who claim everything is predetermined and that we can do nothing to change it, look before they cross the road. ... One cannot base one's conduct on the idea that everything is determined, because one does not know what has been determined. Instead, one has to adopt the effective theory that one has free will and that one is responsible for one's actions. This theory is not very good at predicting human behavior, but we adopt it because there is no chance of solving the equations arising from the fundamental laws. There is also a Darwinian reason that we believe in free will: A society in which the individual feels responsible for his or her actions is more likely to work together and survive to spread its values.

 
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