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Nicolaus Copernicus

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Therefore alongside the ancient hypotheses, which are no more probable, let us permit these new hypotheses also to become known, especially since they are admirable as well as simple and bring with them a huge treasure of very skillful observations. So far as hypotheses are concerned, let no one expect anything certain from astronomy, which cannot furnish it, lest he accept as the truth ideas conceived for another purpose, and depart from this study a greater fool than when he entered it.
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Part of an unsigned foreword to Copernicus' De revolutionibus orbium coelestium, actually written by Andreas Osiander.

 
Nicolaus Copernicus

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Certainly it is permitted to anyone to put forward whatever hypotheses he wishes, and to develop the logical consequences contained in those hypotheses. But in order that this work merit the name of Geometry, it is necessary that these hypotheses or postulates express the result of the more simple and elementary observations of physical figures.

 
Giuseppe Peano
 

I have not been able to discover the cause of those properties of gravity from phenomena, and I frame no hypotheses; for whatever is not deduced from the phenomena is to be called a hypothesis, and hypotheses, whether metaphysical or physical, whether of occult qualities or mechanical, have no place in experimental philosophy.

 
Isaac Newton
 

I have not as yet been able to discover the reason for these properties of gravity from phenomena, and I do not feign hypotheses. For whatever is not deduced from the phenomena must be called a hypothesis; and hypotheses, whether metaphysical or physical, or based on occult qualities, or mechanical, have no place in experimental philosophy. In this philosophy particular propositions are inferred from the phenomena, and afterwards rendered general by induction.

 
Isaac Newton
 

The general laws of Nature are not, for the most part, immediate objects of perception. They are either inductive inferences from a large body of facts, the common truth in which they express, or, in their origin at least, physical hypotheses of a causal nature serving to explain phenomena with undeviating precision, and to enable us to predict new combinations of them. They are in all cases, and in the strictest sense of the term, probable conclusions, approaching, indeed, ever and ever nearer to certainty, as they receive more and more of the confirmation of experience. But of the character of probability, in the strict and proper sense of that term, they are never wholly divested. On the other hand, the knowledge of the laws of the mind does not require as its basis any extensive collection of observations. The general truth is seen in the particular instance, and it is not confirmed by the repetition of instances.

 
George Boole
 

It seems to me what is called for is an exquisite balance between two conflicting needs: the most skeptical scrutiny of all hypotheses that are served up to us and at the same time a great openness to new ideas … If you are only skeptical, then no new ideas make it through to you … On the other hand, if you are open to the point of gullibility and have not an ounce of skeptical sense in you, then you cannot distinguish the useful ideas from the worthless ones.

 
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