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Maimonides

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You are no doubt aware that the Almighty, desiring to lead us to perfection and to improve our state of society, has revealed to us laws which are to regulate our actions. These laws, however, presuppose an advanced state of intellectual culture. We must first form a conception of the Existence of the Creator according to our capabilities; that is, we must have a knowledge of Metaphysics. But this discipline can only be approached after the study of Physics: for the science of Physics borders on Metaphysics, and must even precede it in the course of our studies, as is clear to all who are familiar with these questions.

 
Maimonides

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The first question we should face is: What is the aim of a physical theory? To this question diverse answers have been made, but all of them may be reduced to two main principles:
"A physical theory," certain logicians have replied, "has for its object the explanation of a group of laws experimentally established."
"A physical theory," other thinkers have said, "is an abstract system whose aim is to summarize and classify logically a group of experimental laws without claiming to explain these laws...
Now these two questions — Does there exist a material reality distinct from sensible appearances? and What is the nature of reality? — do not have their source in experimental method, which is acquainted only with sensible appearances and can discover nothing beyond them. The resolution of these questions transcends the methods used by physics; it is the object of metaphysics.
Therefore, if the aim of physical theories is to explain experimental laws, theoretical physics is not an autonomous science; it is subordinate to metaphysics...
Now, to make physical theories depend on metaphysics is surely not the way to let them enjoy the privilege of universal consent.

 
Pierre Duhem
 

Many people would claim that the boundary conditions are not part of physics but belong to metaphysics or religion. They would claim that nature had complete freedom to start the universe off any way it wanted. That may be so, but it could also have made it evolve in a completely arbitrary and random manner. Yet all the evidence is that it evolves in a regular way according to certain laws. It would therefore seem reasonable to suppose that there are also laws governing the boundary conditions.

 
Stephen Hawking
 

I learned about X-ray diffraction, neutron scattering, raman scattering, infrared absorption spectroscopy, heat capacity, transport, time-dependent transport, magnetic resonance, electron diffraction, electron energy loss spectroscopy — all the experimental techniques that constitute the eyes and ears of modern solid state physics. As this occurred I slowly became disillusioned with the reductionist ideal of physics, for it was completely clear that the outcome of these experiments was almost always impossible to predict from first principles, yet was right and meaningful and certainly regulated by the same microscopic laws that work in atoms. Only many years later did I finally understand that this truth, which seems so natural to solid state physicists because they confront experiments so frequently, is actually quite alien to other branches of physics and is vigorously repudiated by many scientists on the grounds that things not amenable to reductionist thinking are not physics.

 
Robert B. Laughlin
 

Physics is the Science of Matter; Metaphysics the Science of Mind — the Science of Being, apart from accidents and properties — Ontology.

 
Horace Mann
 

Our knowledge of physics only takes us back so far. Before this instant of cosmic time, all the laws of physics or chemistry are as evanescent as rings of smoke.

 
Joseph Silk
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