It may be that ultimately the search for dark matter will turn out to be the most expensive and largest null result experiment since the Michelson-Morely experiment, which failed to detect the ether.
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Chapter 4, Dark Matter, p. 77John Moffat (physicist)
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...when the experiment was attempted by Michelson and Morley it failed, thus showing that space and time assumed in the picture were not true to the facts of nature. ...the pattern of events was the same whether the world stood at rest in the supposed ether, or had an ether wind blowing through it at a million miles an hour. It began to look as though the supposed ether was not very important in the scheme of things... and so might as well be abandoned. But if the bell-rope is to be discarded, what is to ring the bell?
James Jeans
(Coining phrase "null hypothesis") In relation to any experiment we may speak of this hypothesis as the “null hypothesis,” and it should be noted that the null hypothesis is never proved or established, but is possibly disproved, in the course of experimentation. Every experiment may be said to exist only in order to give the facts a chance of disproving the null hypothesis.
Ronald Fisher
Why is Einstein's theory better than Lorentz's theory? It would be a mistake to argue that Einstein's theory gives an explanation of Michelson's experiment, since it does not do so. Michelson's experiment is simply taken over as an axiom.
Hans Reichenbach
We must trust to nothing but facts: These are presented to us by Nature, and cannot deceive. We ought, in every instance, to submit our reasoning to the test of experiment, and never to search for truth but by the natural road of experiment and observation.
Antoine Lavoisier
In science, conjecture drives both experiment and theory for it is only by forming conjectures (hypotheses) that we can make the direction of our experiments and theories informed. If such and such is true, then I should be able to do this experiment and look for this particular result or I should be able to find this theoretical formulation. Conversely, experiment and theory drive conjecture. One makes a startling observation or has a sudden insight and begins to speculate on its significance and implications and to draw possible conclusions (conjecture).
Robert Curl
Moffat, John (physicist)
Moffat, Steven
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