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To explain all nature is too difficult a task for any one man or even for any one age. 'Tis much better to do a little with certainty, & leave the rest for others that come after you, than to explain all things by conjecture without making sure of any thing.
--
Statement from unpublished notes for the Preface to Opticks (1704) quoted in Never at Rest: A Biography of Isaac Newton (1983) by Richard S. Westfall, p. 643.

 

Isaac Newton

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You reason well, and your wit is bold, but you are too prejudiced. You do not let your eyes see nor your ears hear, and that which is outside your daily life is not of account to you. Do you not think that there are things which you cannot understand, and yet which are, that some people see things that others cannot? But there are things old and new which must not be contemplated by men's eyes, because they know, or think they know, some things which other men have told them. Ah, it is the fault of our science that it wants to explain all, and if it explain not, then it says there is nothing to explain. But yet we see around us every day the growth of new beliefs, which think themselves new, and which are yet but the old, which pretend to be young, like the fine ladies at the opera.

 

Bram Stoker

 

In the case of the cosmos, [...] even if we don’t understand how it came about, it’s not helpful to postulate a creator, because the creator is the very kind of thing that needs an explanation - and although it's difficult enough to explain how a very simple origin of the universe came into being - how matter and energy, how one or two physical constants came into existence - although it’s difficult enough to think how simplicity came into existence, it’s a hell of a lot harder to think how something as complicated as a God comes into existence - difficult enough to think of how a deist God comes into existence, and even more difficult to think of - how a Christian God, who actually cares about things like sin and gets Himself born of a virgin.

 

Richard Dawkins

 

The mammalian record thus confirms our statement that any animal which is not too strongly conditioned by some special sort of experience is capable of responding to any adequate stimulus. This is what we find in the more uninhibited segments of our human species, and this is what we find among young children who are not too rigorously restrained in their early sex play. Exclusive preferences and patterns of behavior, heterosexual or homosexual, come only with experience, or as a result of social pressures which tend to force an individual into an exclusive pattern of one or the other sort. Psychologists and psychiatrists, reflecting the mores of the culture in which they have been raised, have spent a good deal of time trying explain the origins of homosexual activity; but considering the physiology of sexual response and the mammalian backgrounds of human behavior, it is not so difficult to explain why a human animal does a particular thing sexually. It is more difficult to explain why each and every individual is not involved in every type of sexual activity.

 

Alfred Kinsey

 

To explain, however, everything relating to the nature of this deity, is beyond the power of man, even though the god himself should grant him the ability to understand it: in a case where it seems, to me at least, impossible even mentally to conceive all its extent. And now that we have discussed so much, we must put as it were a seal upon this subject; and to stay a while and pass on to other points no less requiring examination. What then is this seal; and what comprises everything, as it were in a summary of the conception concerning the nature of the god? May He Himself inspire our understanding when we attempt briefly to explain the source out of which he proceeded; and what he is himself; and with what effects he fills the visible world. It must therefore be laid down that the sovereign Sun proceeded from the One God, — One out of the one Intelligible world; he is stationed in the middle of the Intelligible Powers, according to the strictest sense of "middle position;" bringing the last with the first into a union both harmonious and loving, and which fastens together the things that were divided: containing within himself the means of perfecting, of cementing together, of generative life, and of the uniform existence, and to the world of Sense, the author of all kinds of good; not merely adorning and cheering it with the radiance wherewith he himself illumines the same, but also by making subordinate to himself the existence of the Solar Angels; and containing within himself the unbegotten Cause of things begotten; and moreover, prior to this, the unfading, unchanging source of things eternal.
All, therefore, that was fitting to be said touching the nature of this deity (although very much has been passed over in silence) has now been stated at some length.

 

Julian (Emperor)

 

One day, when Charles was a very small boy, he came up to his father and showed him a book of logarithms, with the request, "Please explain." Mr. Dodgson told him that he was much too young to understand anything about such a difficult subject. The child listened to what his father said, and appeared to think it irrelevant, for he still insisted, "But, please, explain!"

 

Lewis Carroll