The emergence of a unified cognitive moment relies on the coordination of scattered mosaics of functionally specialized brain regions. Here we review the mechanisms of large-scale integration that counterbalance the distributed anatomical and functional organization of brain activity to enable the emergence of coherent behaviour and cognition. Although the mechanisms involved in large-scale integration are still largely unknown, we argue that the most plausible candidate is the formation of dynamic links mediated by synchrony over multiple frequency bands.
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Francisco Varela*, Jean-Philippe Lachaux*, Eugenio Rodriguez, and Jacques Martinerie (2001) "The brainweb: phase synchronization and large-scale integration" in: Nature Rviews Vol 2. (April 2001). p.229 (online)Francisco Varela
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Addictive drugs misuse the brain’s existing pre-programming, activating reward mechanisms and extreme feelings of pleasure. When stimulated, the brain’s pleasure centres emit signals to repeat the behaviour. In this sense, the brain is pre-programmed to feel good.
Nayef Al-Rodan
This has been a long personal endeavor of mine. Twenty-five years ago ... I just fell in love with brains. ... I decided to dedicate my life to it. It has been a long road, it's up and down, it's actually not an easy thing to do, to say I'm going to work on large-scale theories of brain function. It was not something you could do in the 1980s. There was no place you could go. ... Nobody was doing the large-scale theory. That's changed in only recent years and I started my institute, the Redwood Neuroscience Institute, to create a place where you could focus on this problem. And, I think, that's really all it took.
Jeff Hawkins
The difficulty of dealing with St. Thomas Aquinas in this brief article is the difficulty of selecting that aspect of a many-sided mind which will best suggest its size or scale. Because of the massive body which carried his massive brain, he was called "The Ox"; but any attempt to boil down such a brain into tabloid literature passes all possible jokes about an ox in a teacup. He was one of the two or three giants; one of the two or three greatest men who ever lived; and I should never be surprised if he turned out, quite apart from sanctity, to be the greatest of all. Another way of putting the problem is to say that proportion alters according to what other men we are at the moment classing him with or pitting him against. We do not get the scale until we come to the few men in history who can be his rivals.
Thomas Aquinas
The difficulty of dealing with St. Thomas Aquinas in this brief article is the difficulty of selecting that aspect of a many-sided mind which will best suggest its size or scale. Because of the massive body which carried his massive brain, he was called "The Ox"; but any attempt to boil down such a brain into tabloid literature passes all possible jokes about an ox in a teacup. He was one of the two or three giants; one of the two or three greatest men who ever lived; and I should never be surprised if he turned out, quite apart from sanctity, to be the greatest of all. Another way of putting the problem is to say that proportion alters according to what other men we are at the moment classing him with or pitting him against. We do not get the scale until we come to the few men in history who can be his rivals.
Thomas Aquinas
This organization of functional discourse is of vital importance; it serves as a vehicle of coordination and subordination. The unified, functional language is an irreconcilably anti-critical and anti-dialectical language. In it, operational and behavioral rationality absorbs the transcendent, negative, oppositional elements of Reason.
Herbert Marcuse
Varela, Francisco
Varese, Edgard
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