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Francis Crick

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The ultimate aim of the modern movement in biology is in fact to explain all biology in terms of physics and chemistry.
--
Seattle: University of Washington Press, 1966, p. 10.

 
Francis Crick

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[Biology has] become the paramount science, exceeding other disciplines, including physics and chemistry at least, in the creative tumult of its disciplines and disputations. [...] I'll also be so bold at this point to suggest that we are now at the edge of establishing the two fundamental laws of biology: The first law is that all of the phenomena of biology, the entities and the processes, are ultimately obedient to the laws of physics and chemistry. Not immediately reducible to them, but ultimately consistent and in consilience with them, by a cause and effect explanation. The second law is that all biological phenomena, these entities and processes that define life itself, have arisen by evolution through natural selection.

 
E. O. Wilson
 

The recognition of certain basic impossibilities has laid the foundations of some major principles of physics and chemistry; similarly, recognition of the impossibility of understanding living things in terms of physics and chemistry, far from setting limits to our understanding of life, will guide it in the right direction. And even if the demonstration of this impossibility should prove of no great advantage in the pursuit of discovery, such a demonstration would help to draw a truer image of life and man than that given us by the present basic concepts of biology.

 
Michael Polanyi
 

With the hubris common to physicists, I have always felt that I have known what good science is — it is theory cast in terms of mechanisms that describe how parts of the universe behave. With sometimes immense historical delay, these mechanisms always move towards being grounded in the larger mechanistic view of the universe. Theories always propose a view of how the universe is. They can never be effectively argued to be true, but only be brought before the bar of empirical evidence. All the modern concern for contextualism, hermeneutics and the social determination of meaning has its point, but is a mere footnote to the massive evidence for this view of science. The overwhelming success within this framework of modern biology over the last half century has provided another major confirmation, if one is needed. Someday we will get another striking confirmation from cognitive science. Though it can be argued that we are well on our way, we still have an immense distance to go. Arguments are no match for the evidence that cognitive science does not control its subject the way physics, chemistry and now biology do.

 
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I can’t be as confident about computer science as I can about biology. Biology easily has 500 years of exciting problems to work on. It’s at that level.

 
Donald Knuth
 

Somehow, the practice of astronomy, physics, chemistry or biology normally fails to evoke the controversies over fundamentals that today seem endemic among, say, psychologists or sociologists. Attempting to discover the source of that difference led me to recognize the role in scientific research of what I have since called “paradigms.” These I take to be universally recognized scientific achievements that for a time provide model problems and solutions for a community of practitioners.

 
Thomas Samuel Kuhn
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