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Premature optimization is the root of all evil (or at least most of it) in programming.
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p. 671
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Premature optimization is the root of all evil.
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Variant in Knuth, "Structured Programming with Goto Statements". Computing Surveys 6:4 (December 1974), pp. 261–301, §1.

 

Donald Knuth

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Premature optimization is the root of all evil.

 

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In today's computer science curricula [...] almost all their time is devoted to formal classification of syntactic language types, defeatist unsolvability theories, folklore about systems programming, and generally trivial fragments of "optimization of logic design"–the latter often in situations where the art of heuristic programming has far outreached the special-case "theories" so grimly taught and tested–and invocations about programming style almost sure to be outmoded before the student graduates.

 

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My favorite programming languages are Lisp and C. However, since around 1992 I have worked mainly on free software activism, which means I am too busy to do much programming. Around 2008 I stopped doing programming projects.

 

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So you think that money is the root of all evil? Have you ever asked what is the root of money? Money is a tool of exchange, which can't exist unless there are goods produced and men able to produce them. Money is the material shape of the principle that men who wish to deal with one another must deal by trade and give value for value. Money is not the tool of the moochers, who claim your product by tears or of the looters, who take it from you by force. Money is made possible only by the men who produce. Is this what you consider evil?

 

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However, many applied optimization problems have not been considered yet. It is necessary to use optimization methods of quantum and bio-molecular systems, because of the practical importance of the implementation of physical processes satisfying the required quality criteria. Most of the attention is focused on the following problems: … 2. Mathematical modeling of controlled physical and chemical processes in the brain; [to] consider the brain as a quantum macroscopic object (Gomatam, 1999).

 

Ravi Gomatam