Most SF is about madness, or what is currently ruled to be madness; this is part of its attraction — it's always playing with how much the human mind can encompass.
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"In Conversation: Brian Aldiss & James Blish" in Cypher (October 1973); republished in The Tale That Wags the God (1987) by James BlishBrian Aldiss
I am interested in madness. I believe it is the biggest thing in the human race, and the most constant. How do you take away from a man his madness without also taking away his identity? Are we sure it is desirable for a man's spirit not to be at war with itself, or that it is better to be serene and ready to go to dinner than to be excited and unwilling to stop for a cup of coffee, even?
William Saroyan
The constitution of madness as a mental illness, at the end of the eighteenth century, affords the evidence of a broken dialogue, posits the separation as already effected, and thrusts into oblivion all those stammered, imperfect words without fixed syntax in which the exchange between madness and reason was made. The language of psychiatry, which is a monologue of reason about madness, has been established only on the basis of such a silence.
Michel Foucault
In this century the writer has carried on a conversation with madness. We might almost say of the twentieth-century writer that he aspires to madness. Some have made it, of course, and they hold special places in our regard. To a writer, madness is a final distillation of self, a final editing down. It's the drowning out of false voices.
Don DeLillo
In the Renaissance, madness was present everywhere and mingled with every experience by its images or its dangers. During the classical period, madness was shown, but on the other side of bars; if present, it was at a distance, under the eyes of a reason that no longer felt any relation to it and that would not compromise itself by too close a resemblance. Madness had become a thing to look at: no longer a monster inside oneself, but an animal with strange mechanisms, a bestiality from which man had long since been suppressed.
Michel Foucault
To say that war is madness is like saying that sex is madness: true enough, from the standpoint of a stateless eunuch, but merely a provocative epigram for those who must make their arrangements in the world as given.
John Updike
Aldiss, Brian
Aldrich, Henry
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