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During all those years of experimentation and research, I never once made a discovery. All my work was deductive, and the results I achieved were those of invention, pure and simple. I would construct a theory and work on its lines until I found it was untenable. Then it would be discarded at once and another theory evolved. This was the only possible way for me to work out the problem. ... I speak without exaggeration when I say that I have constructed 3,000 different theories in connection with the electric light, each one of them reasonable and apparently likely to be true. Yet only in two cases did my experiments prove the truth of my theory. My chief difficulty was in constructing the carbon filament. . . . Every quarter of the globe was ransacked by my agents, and all sorts of the queerest materials used, until finally the shred of bamboo, now utilized by us, was settled upon.
--
On his years of research in developing the electric light bulb, as quoted in "Talks with Edison" by George Parsons Lathrop in Harpers magazine, Vol. 80 (February 1890), p. 425

 

Thomas Alva Edison

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Through all the years of experimenting and research, I never once made a discovery. I start where the last man left off. ... All my work was deductive, and the results I achieved were those of invention pure and simple.

 

Thomas Alva Edison

 

Any physical theory is always provisional, in the sense that it is only a hypothesis: you can never prove it. No matter how many times the results of experiments agree with some theory, you can never be sure that the next time the result will not contradict the theory. On the other hand, you can disprove a theory by finding even a single observation that disagrees with the predictions of the theory. As philosopher of science Karl Popper has emphasized, a good theory is characterized by the fact that it makes a number of predictions that could in principle be disproved or falsified by observation. Each time new experiments are observed to agree with the predictions the theory survives, and our confidence in it is increased; but if ever a new observation is found to disagree, we have to abandon or modify the theory.

 

Stephen Hawking

 

Pytheos made a mistake by not observing that the arts are each composed of two things, the actual work and the theory of it. One of these, the doing of the work, is proper to men trained in the individual subject, while the other the theory is common to all scholars.

 

Vitruvius

 

It was, for all I know, the first deductive theory of the world, the first deductive cosmology: One further step led to theoretical physics, and to the atomic theory.

 

Parmenides

 

I don't believe that the ultimate theory will come by steady work along existing lines. We need something new. We can't predict what that will be or when we will find it because if we knew that, we would have found it already! It could come in the next 20 years, but we might never find it.

 

Stephen Hawking