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The atomic hypothesis which had worked so splendidly in Physics breaks down in Physics.
--
Francis Ysidro Edgeworth, p. 286

 

John Maynard Keynes

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With the coming of the twentieth century, there came into being a new physics which was especially concerned with phenomenon on the atomic and sub-atomic scale. ...A preliminary glance over the vast territory of this new physics reveals three outstanding landmarks.

 

James Jeans

 

However the development proceeds in detail, the path so far traced by the quantum theory indicates that an understanding of those still unclarified features of atomic physics can only be acquired by foregoing visualization and objectification to an extent greater than that customary hitherto. We have probably no reason to regret this, because the thought of the great epistemological difficulties with which the visual atom concept of earlier physics had to contend gives us the hope that the abstracter atomic physics developing at present will one day fit more harmoniously into the great edifice of Science.

 

Werner Heisenberg

 

On the side of physics, there were a few key figures in Oxford who realized, in all probability unlike the majority of their colleagues in the physics department, that physics without interpretation is only part of the story, and that theories like quantum mechanics need careful foundational reflection.

 

Harvey (philosopher) Brown

 

In the past century, and even nowadays, one could encounter the opinion that in physics nearly everything had been done. There allegedly are only dim 'cloudlets' in the sky or theory, which will soon be eliminated to give rise to the 'theory of everything'. I consider these views as some kind of blindness. The entire history of physics, as well as the state of present-day physics and, in particular, astrophysics, testifies to the opposite. In my view we are facing a boundless sea of unresolved problems.

 

Vitaly Ginzburg

 

The materialist critics argue that insuperable difficulties are encountered by the hypothesis that immaterial mental events can act in any way on material structures such as neurons. Such a presumed action is alleged to be incompatible with the conservation laws of physics, in particular of the first law of thermodynamics. This objection would certainly be sustained by nineteenth century physicists, and by neuroscientists and philosophers who are still ideologically in the physics of the nineteenth century, not recognizing the revolution wrought by quantum physicists in the twentieth century.

 

John Carew Eccles