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Paradox is the sharpest scalpel in the satchel of science. Nothing concentrates the mind as effectively, regardless of whether it pits two competing theories against each other, or theory against observation, or a compelling mathematical deduction against ordinary common sense.
--
Chapter 23, Black Holes, Where information goes to hide, p. 204

 

Hans Christian von Baeyer

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Any physical theory is always provisional, in the sense that it is only a hypothesis: you can never prove it. No matter how many times the results of experiments agree with some theory, you can never be sure that the next time the result will not contradict the theory. On the other hand, you can disprove a theory by finding even a single observation that disagrees with the predictions of the theory. As philosopher of science Karl Popper has emphasized, a good theory is characterized by the fact that it makes a number of predictions that could in principle be disproved or falsified by observation. Each time new experiments are observed to agree with the predictions the theory survives, and our confidence in it is increased; but if ever a new observation is found to disagree, we have to abandon or modify the theory.

 

Stephen Hawking

 

The theory of relativity is a beautiful example of the basic character of the modern development of theory. That is to say, the hypotheses from which one starts become ever more abstract and more remote from experience. But in return one comes closer to the preeminent goal of science, that of encompassing a maximum of empirical contents through logical deduction with a minimum of hypotheses or axioms. The intellectual path from the axioms to the empirical contents or to the testable consequences becomes, thereby, ever longer and more subtle. The theoretician is forced, ever more, to allow himself to be directed by purely mathematical, formal points of view in the search for theories, because the physical experience of the experimenter is not capable of leading us up to the regions of the highest abstraction. Tentative deduction takes the place of the predominantly inductive methods appropriate to the youthful state of science. Such a theoretical structure must be quite thoroughly elaborated in order for it to lead to consequences that can be compared with experience. It is certainly the case that here, as well, the empirical fact is the all-powerful judge. But its judgment can be handed down only on the basis of great and difficult intellectual effort that first bridges the wide space between the axioms and the testable consequences. The theorist must accomplish this Herculean task with the clear understanding that this effort may only be destined to prepare the way for a death sentence for his theory. One should not reproach the theorist who undertakes such a task by calling him a fantast; instead, one must allow him his fantasizing, since for him there is no other way to his goal whatsoever. Indeed, it is no planless fantasizing, but rather a search for the logically simplest possibilities and their consequences.

 

Albert Einstein

 

Whenever faced with two competing theories for the same set of observations I have always found that the theory which was more aesthetically satisfying is also the correct one.

 

Abdus Salam

 

In science, conjecture drives both experiment and theory for it is only by forming conjectures (hypotheses) that we can make the direction of our experiments and theories informed. If such and such is true, then I should be able to do this experiment and look for this particular result or I should be able to find this theoretical formulation. Conversely, experiment and theory drive conjecture. One makes a startling observation or has a sudden insight and begins to speculate on its significance and implications and to draw possible conclusions (conjecture).

 

Robert Curl

 

There is an honesty in science which demands that the best means be used for the determination of truth. Certainly there are many sorts of truth in the universe, and many aspects of truth must be taken into account if man is to live most effectively in the social organization to which he belongs. But in regard to matter---the stuff of which both non-living materials and living organisms are made---scientists believe that there is no better way of obtaining information than that provided by human sense organs. No theory, no philosophy, no body of theology, no political expediency, no wishful thinking, can provide a satisfactory substitute for the observation of material objects and of the way in which they behave. (page 9).

 

Alfred Kinsey