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It is also a good rule not to put overmuch confidence in the observational results that are put forward until they are confirmed by theory.
--
As quoted in "Annals of Science II-DNA" by Horace Freeland Judson in The New Yorker (4 December 1978), p. 132

 

Arthur Stanley Eddington

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Of course, we must avoid postulating a new element for each new phenomenon. But an equally serious mistake is to admit into the theory only those elements which can now be observed. For the purpose of a theory is not only to correlate the results of observations that we already know how to make, but also to suggest the need for new kinds of observations and to predict their results. In fact, the better a theory is able to suggest the need for new kinds of observations and to predict their results correctly, the more confidence we have that this theory is likely to be good representation of the actual properties of matter and not simply an empirical system especially chosen in such a way as to correlate a group of already known facts.

 

David Bohm

 

Any physical theory is always provisional, in the sense that it is only a hypothesis: you can never prove it. No matter how many times the results of experiments agree with some theory, you can never be sure that the next time the result will not contradict the theory. On the other hand, you can disprove a theory by finding even a single observation that disagrees with the predictions of the theory. As philosopher of science Karl Popper has emphasized, a good theory is characterized by the fact that it makes a number of predictions that could in principle be disproved or falsified by observation. Each time new experiments are observed to agree with the predictions the theory survives, and our confidence in it is increased; but if ever a new observation is found to disagree, we have to abandon or modify the theory.

 

Stephen Hawking

 

Taking experimental results and observations for granted and putting the burden of proof on the theory means taking the observational ideology for granted without having ever examined it.

 

Paul Karl Feyerabend

 

For the truth of the conclusions of physical science, observation is the supreme Court of Appeal. It does not follow that every item which we confidently accept as physical knowledge has actually been certified by the Court; our confidence is that it would be certified by the Court if it were submitted. But it does follow that every item of physical knowledge is of a form which might be submitted to the Court. It must be such that we can specify (although it may be impracticable to carry out) an observational procedure which would decide whether it is true or not. Clearly a statement cannot be tested by observation unless it is an assertion about the results of observation. Every item of physical knowledge must therefore be an assertion of what has been or would be the result of carrying out a specified observational procedure.

 

Arthur Stanley Eddington

 

If we consider further the manifold relations of this mathematical theory to civil uses and the technical arts, we shall recognize completely the extent of its applications. It is evident that it includes an entire series of distinct phenomena, and that the study of it cannot be omitted without losing a notable part of the science of nature.
The principles of the theory are derived, as are those of rational mechanics, from a very small number of primary facts, the causes of which are not considered by geometers, but which they admit as the results of common observations confirmed by all experiment.

 

Joseph Fourier